What test can be performed to study the association between case/control status and risk score? Specifically, we are interested in testing whether cases tend to have consistently higher risk scores or consistently lower risk scores than controls.

Ophthalmology

A caseˆ’control study was performed among 145 subjects with macular degeneration and 34 controls, all of whom were 70- to 79-year-old women. A genetic risk score was developed to help differentiate the cases from the controls. The risk score was categorized into six groups (1, 2, 3, 4, 5, 6), with 6 being the highest risk and 1 being the lowest risk.The data in Table 10.48 were obtained relating the risk score to case/control status.

Table 10.48: Association between a genetic risk score and macular degeneration

 

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Risk score Controls Cases 3 11 2 3 3 10 5 11 6 108 4 Total 145 34