A mutation in the Ras protein renders Ras constitutively active (Ras D ). What is constitutive activation?

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A mutation in the Ras protein renders Ras constitutively active (Ras^D). What is constitutive activation? How is constitutively active Ras cancer promoting? What type of mutation might render the following proteins constitutively active:

(a) Smad3

(b) MAP kinase

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Molecular Cell Biology

ISBN: 978-1429234139

7th edition

Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott

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Question Posted: Apr 17, 2018 05:29 AM

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A mutation in the Ras protein renders Ras constitutively active (Ras D ). What is constitutive activation?

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Constitutive activation is the alteration of a protein or signaling pathway such that it is function...View the full answer

Molecular Cell Biology

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