DNA-repair systems are responsible for maintaining genomic fidelity in normal cells despite the high frequency with which
Question:
DNA-repair systems are responsible for maintaining genomic fidelity in normal cells despite the high frequency with which mutational events occur. What type of DNA mutation is generated by
(a) UV irradiation
(b) Ionizing radiation?
Describe the system responsible for repairing each of these types of mutations in mammalian cells. Postulate why a loss of function in one or more DNA-repair systems typifies many cancers.
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Step by Step Answer:
a UV irradiation causes thyminethymine dimers These are usually repaired by the nucleotide excisionr...View the full answer
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Related Book For 
Molecular Cell Biology
ISBN: 978-1429234139
7th edition
Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott
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