High doses of caffeine interfere with the DNA damage response in mammalian cells. Why then do you suppose the Surgeon General has not yet issued an appropriate warning to heavy coffee and cola drinkers? A typical cup of coffee (150 mL) contains 100 mg of caffeine (196 g/ mole). How many cups of coffee would you have to drink to reach the dose (10 mM) required to interfere with the DNA damage response? (A typical adult contains about 40 liters of water.)