How is the signal generated by binding of TGF-13 to cellsurface receptors transmitted to the nucleus, where
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How is the signal generated by binding of TGF-13 to cellsurface receptors transmitted to the nucleus, where changes in target gene expression occur? What activity in the nucleus ensures that the concentration of active Smads closely reflects the level of activated TGF-13 receptors on the cell surface?
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TGF binds to its type II receptor either directly or when presented by the type III receptor The typ...View the full answer
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Related Book For 
Molecular Cell Biology
ISBN: 978-1429234139
7th edition
Authors: Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Matthew P. Scott
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