For several decades, the dogma in biology has been that molecular reactions in living cells are catalyzed by enzymes composed of polypeptides. We now know that the introns of some precursor RNA molecules such as the rRNA precursors in Tetrahymena are removed autocatalytically (self-spliced) with no involvement of any catalytic protein. What does the demonstration of auto catalytic splicing indicate about the dogma that biological reactions are always catalyzed by proteinaceous enzymes?