15. Challenge: What is the ratio of protonated [HA] vs. deprotonated [A-] species for the following...
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15. Challenge: What is the ratio of protonated [HA] vs. deprotonated [A-] species for the following compounds at pH 2, 5, 9, and 14? pKa of each is given as: 10.0, 10.6, 19.2, 4.87 (L to R) OH OH SH Hint: Derive the ratio from henderson hasselbalch equation. 16. Medicinal chemists make slight modifications to molecules in the attempt to increase the efficacy of the potential drug while also decreasing toxicity and side effects. Lansoprazole (Prevacid) is a proton-pump inhibitor that is used in the treatment of ulcers. Would the proton indicated in lansoprazole be more or less acidic than the proton indicated in the analogous compound? Would these compounds be more likely to act as an acid or a base? N- lansoprazole analogue 17. For each set of common laboratory solvents, identify the compound that is more acidic. of H,C CH, methanol acetone Vs. CI H-C-CI dichloromethane hexane vs. ethyl acetate water v. 18. Rank these compounds in terms of increasing acidity HNO, H,SO, HF H,CO3 a. NH, CH, H,O HCI 4/7 b. NH, с. HF он d. 15. Challenge: What is the ratio of protonated [HA] vs. deprotonated [A-] species for the following compounds at pH 2, 5, 9, and 14? pKa of each is given as: 10.0, 10.6, 19.2, 4.87 (L to R) OH OH SH Hint: Derive the ratio from henderson hasselbalch equation. 16. Medicinal chemists make slight modifications to molecules in the attempt to increase the efficacy of the potential drug while also decreasing toxicity and side effects. Lansoprazole (Prevacid) is a proton-pump inhibitor that is used in the treatment of ulcers. Would the proton indicated in lansoprazole be more or less acidic than the proton indicated in the analogous compound? Would these compounds be more likely to act as an acid or a base? N- lansoprazole analogue 17. For each set of common laboratory solvents, identify the compound that is more acidic. of H,C CH, methanol acetone Vs. CI H-C-CI dichloromethane hexane vs. ethyl acetate water v. 18. Rank these compounds in terms of increasing acidity HNO, H,SO, HF H,CO3 a. NH, CH, H,O HCI 4/7 b. NH, с. HF он d.
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