Rule of Three has been proposed for fragment molecules in fragment-based drug design (a variation on Lipinskis
Fantastic news! We've Found the answer you've been seeking!
Question:
“Rule of Three” has been proposed for fragment molecules in fragment-based drug design (a variation on Lipinski’s Rule of Five). This alternative set of rules states that:
- Molecular weight < 300
- Hydrogen bond donors ≤ 3
- Hydrogen bond acceptors ≤ 3
- LogP ≤ 3
- Compounds 1-3 are three of the most potent fragments from a recent screening study. For each compound, state the number of hydrogen bond donors and hydrogen bond acceptors. (3 marks)
- Based on your donor/acceptor counts, briefly comment on the reliability of rules such as the “Rule of Three”. (1 mark)
- What molecular property is LogP a measure of? (1 mark)
Related Book For
Posted Date: