Explain the fact that, although hemiacetal formation between methanol and cyclohexanone is thermodynamically disfavored, addition of methanol

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Explain the fact that, although hemiacetal formation between methanol and cyclohexanone is thermodynamically disfavored, addition of methanol to cyclopropanone goes essentially to completion:

HO НО OCH3 + CH;OH 1

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Organic Chemistry structure and function

ISBN: 978-1429204941

6th edition

Authors: K. Peter C. Vollhardt, Neil E. Schore

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Question Posted: May 07, 2020 08:35 AM

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Explain the fact that, although hemiacetal formation between methanol and cyclohexanone is thermodynamically disfavored, addition of methanol

Question:

HO НО OCH3 + CH;OH 1

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Hemiacetal formation bw methanol and cyclohexanone is thermodynamically unfavorable This can be ...View the full answer

Organic Chemistry structure and function

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