Like many chiral pharmaceuticals, Ritalin, widely used to treat attention defi cit disorder, is synthesized and marketed
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Like many chiral pharmaceuticals, Ritalin, widely used to treat attention defi cit disorder, is synthesized and marketed as a racemic mixture. In 2003, a new and potentially practical synthetic route to the active enantiomer (see structure, margin) was described. The fi rst step is shown below, the reaction of dimethyl sulfate with a six-membered ring lactam. Propose a mechanism for this reaction.
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Related Book For
Organic Chemistry structure and function
ISBN: 978-1429204941
6th edition
Authors: K. Peter C. Vollhardt, Neil E. Schore
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