Quinolines are heterocycles that are widely used in medicinal chemistry because of the diversity of biological activity

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Quinolines are heterocycles that are widely used in medicinal chemistry because of the diversity of biological activity — including anticancer utility — that their derivatives display. A short synthesis of 3-acyldihydroquinolines (which may be converted into 3-acylquinolines by mild oxidation) is shown below. Propose a mechanism for this process. 

CH3 Base catalyst CH3 `NH2 N' H

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Organic Chemistry structure and function

ISBN: 978-1429204941

6th edition

Authors: K. Peter C. Vollhardt, Neil E. Schore

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