The amino acid sequence of met-enkephalin, a brain peptide with powerful opiatelike biological activity, is Tyr-Gly-Gly-Phe-Met. What would be the products of step-by-step Edman degradation of met-enkephalin? 

The peptide shown in Problem 42(d) is leu-enkephalin, a relative of met-enkephalin with similar properties. How would the results of Edman degradation of leu-enkephalin differ from those of met-enkephalin? 

Problem 42(d)

Transcribed Image Text:

OH CH2 O CH2 O CH,CH(CH3)2 HaN—CH—С—NH—СH2 —С-NH—СH2—С-NH—СH -С—NH —CH -COO