The nootkatones are bicyclic ketones responsible for the flavor and aroma of grapefruits. Nootkatones also repel termites and are used commercially to protect wood structures from termite infestation. Fill in the missing reagents in the partial synthetic sequence for the preparation of isonootkatone shown on the next page. More than one synthetic step may be needed for each transformation. 

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HO,C- CO,H CO2CH3 Br Br CO,CH3 Nootkatone Isonootkatone