Acid-catalyzed hydrolysis of a nitrile to give a carboxylic acid occurs by initial Protonation of the nitrogen
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Acid-catalyzed hydrolysis of a nitrile to give a carboxylic acid occurs by initial Protonation of the nitrogen atom, followed by nucleophilic addition of water. Review the mechanism of base-catalyzed nitrile hydrolysis in Section 20.7, and then write all the steps involved in the acid-catalyzed reaction, using curved arrows to represent electron flow in each step.
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RCEN H3O NH amide NH OH OH protonation NH OH HO protonation RCENH loss of proton ...View the full answer
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