Question: The mechanism involved in the reaction catalyzed by phosphoglyceromutase is
The mechanism involved in the reaction catalyzed by phosphoglyceromutase is known to involve a phosphory-lated enzyme intermediate. If 3-phosphoglycerate is radioactively labeled with 32P, the product of the reaction, 2-phosphoglycerate, does not have any radioactive label. Design a mechanism to explain these facts.
Answer to relevant QuestionsIf lactic acid is the buildup product of strenuous muscle activity, why is sodium lactate often given to hospital patients intra-venously? What is the Warburg effect, and what does it have to do with the topics of this chapter? Which steps of glycolysis are irreversible? What bearing does this observation have on the reactions in which gluconeogen-esis differs from glycolysis? What is the connection between material in this chapter and hemolytic anemia? What are the similarities and differences between the re-actions catalyzed by pyruvate dehydrogenase and α-ketoglutarate dehydrogenase?
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