Specific DNA-binding proteins mainly contact DNA through hydrogen bonds in the major groove of B-DNA. (a) Why
Question:
(a) Why might sequence-specific binding be more common in the major groove than in the minor groove?
(b) What hydrogen-bond contacts can proteins make with the bases in the major groove?
Are these different from those in the minor groove?
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Related Book For
Fundamentals of biochemistry Life at the Molecular Level
ISBN: 978-0470547847
4th edition
Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt
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