Identify the enzymes in Table 12-1 whose catalytic efficiencies are near the diffusion-controlled limit. Table 12-1 Enzyme

Identify the enzymes in Table 12-1 whose catalytic efficiencies are near the diffusion-controlled limit.

Table 12-1

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Enzyme Acetylcholinesterase Carbonic anhydrase Catalase Chymotrypsin Fumarase Urease Substrate Acetylcholine CO HCO3 HO N-Acetylglycine ethyl ester N-Acetylvaline ethyl ester N-Acetyltyrosine ethyl ester Fumarate Malate Urea KM (M) 9.5 x 10-5 1.2 x 10-2 2.6 10-2 2.5 x 10-2 4.4 X 10-1 8.8 x 10-2 6.6 X 10-4 5.0 x 10-6 2.5 X 10 2.5 x 10- kcat (S-) 1.4 x 104 1.0 X 106 4.0 X 105 1.0 X 107 5.1 x 10-2 1.7 X 10-1 1.9 X 10 8.0 X 10 9.0 10 1.0 X 104 Keat/KM (M-.s-) 1.5 X 108 8.3 X 107 1.5 X 107 4.0 X 108 1.2 x 10-1 1.9 2.9 105 1.6 X 108 3.6 X 107 4.0 X 105