What is the expected number of events that need to be realized in each group to achieve

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What is the expected number of events that need to be realized in each group to achieve 80% power to detect an IRR for breast cancer of 1.5 for current OC users vs. never OC users under the same assumptions as in Problem 14.5?


Cancer

The data relating oral-contraceptive (OC) use and the incidence of breast cancer in the age group 40ˆ’44 in the NHS are given in Table 14.31.

Table 14.31: Relationship between breast-cancer incidence and OC use among 40- to 44-year-old women in the NHS

 Number of Number of OC-use group person-years 4,761 121,091 cases Current users Past users Never users 13 164 113 98,091

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