Synthesis of the purine nucleotides AMP and GMP proceeds by a branched pathway starting with ribose 5-phosphate
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Synthesis of the purine nucleotides AMP and GMP proceeds by a branched pathway starting with ribose 5-phosphate (R5P), as shown schematically in Figure Q3–4. Using the principles of feedback inhibition, propose a regulatory strategy for this pathway that ensures an adequate supply of both AMP and GMP and minimizes the buildup of the intermediates (A–I) when supplies of AMP and GMP are adequate.
Figure Q3–4
Transcribed Image Text:
F+ G AMP R5P A B C- D E I- GMP
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Related Book For
Molecular Biology Of The Cell
ISBN: 9780815344322
6th Edition
Authors: Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
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