In The Chemistry of Complex Cross Couplings we showed a Heck reaction used in the synthesis of
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In “The Chemistry of… Complex Cross Couplings” we showed a Heck reaction used in the synthesis of ecteinascidin 743, a natural compound with anticancer activity isolated from the marine tunicate Ecteinascidia turbinate. Write a mechanism for this reaction, using PdL2 to represent the palladium catalyst and abbreviating the complicated structures of the ecteinascidin synthetic intermediates as appropriate.
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PdCl2 is attached to PdL via a linker L1 to form the initial step of the reaction PdL2 undergoes a t...View the full answer
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Related Book For
Organic Chemistry
ISBN: 978-1118875766
12th Edition
Authors: T. W. Graham Solomons, Craig B. Fryhle, Scott A. Snyder
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