Pralidoxime iodide is a general antidote for poisoning by many insecticides. The drug is made in two

Question:

Pralidoxime iodide is a general antidote for poisoning by many insecticides. The drug is made in two steps starting with pyridine-2-carbaldehyde.

(a) Show the mechanism of the reaction of hydroxylamine (NH₂OH) with pyridine-2-carbaldehyde, and give the structure of A.

(b) Reaction of A with iodomethane to give pralidoxime iodide is an S_N2 reaction. Show the mechanism.

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Fundamentals Of Organic Chemistry

ISBN: 9781439049716

7th Edition

Authors: John E. McMurry

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Question Posted: Jul 24, 2023 03:47 AM

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Pralidoxime iodide is a general antidote for poisoning by many insecticides. The drug is made in two

Question:

O=U NH2OH Pyridine-2-carbaldehyde A CH₂I CH3 OH H Pralidoxime iodide

Step by Step Answer:

a Mechanism of the reaction of hydroxylamine NH2OH with pyridine2carbaldehyde Step 1 Formation of Im...View the full answer

Fundamentals Of Organic Chemistry

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