2. Suppose that a two-arm clinical trial is being designed to test if a new drug...
Fantastic news! We've Found the answer you've been seeking!
Question:
Transcribed Image Text:
2. Suppose that a two-arm clinical trial is being designed to test if a new drug is equivalent to the existing drug in delaying terminally ill liver cancer patients. Suppose that two drugs will be considered to be equivalent if the difference in the proportions of subjects who survive at least 3 years after the surgery does not exceed 8% (0.08) (FDA requires ±20% of the overall average as the equivalence limit). Each group received 40 subjects, the sample proportions for the existing and new treatment are 40% and 45%. Test the null hypothesis of non-equivalence at the 5% level. 2. Suppose that a two-arm clinical trial is being designed to test if a new drug is equivalent to the existing drug in delaying terminally ill liver cancer patients. Suppose that two drugs will be considered to be equivalent if the difference in the proportions of subjects who survive at least 3 years after the surgery does not exceed 8% (0.08) (FDA requires ±20% of the overall average as the equivalence limit). Each group received 40 subjects, the sample proportions for the existing and new treatment are 40% and 45%. Test the null hypothesis of non-equivalence at the 5% level.
Expert Answer:
Answer rating: 100% (QA)
We are asked to test the null hypothesis of non equivalence ie the difference in the proportions of ... View the full answer
Related Book For
Posted Date:
Students also viewed these mathematics questions
-
Water is flowing at a rate of 6 m'/min from a reservoir shaped like a hemispherical bowl of radius 13 m, shown below. The volume of water in a hemispherical bowl of radius R is V = (3R - 2) when the...
-
A stratified sample is being designed to estimate the prevalence p of a rare characteristic, say the proportion of residents in Milwaukee, Wisconsin, who have Lyme disease. Stratum 1, with N1 units,...
-
A stratified sample is being designed to estimate the prevalence p of a rare characteristic, say the proportion of residents in Milwaukee, Wisconsin, who have Lyme disease. Stratum 1, with N1 units,...
-
Lionel Train Company has the following information for this year and next year. Current Next Year Year Trains purchased 40,000 48,000 Trains scrapped in production 4,000 3,000 Trains sold 36,000...
-
Refer to Exercise 23-8. Hart Company records standard costs in its accounts and its material variances in separate accounts when it assigns materials costs to the Goods in Process Inventory account....
-
AMT, Inc., is considering the purchase of a digital camera for maintenance of design specifications by feeding digital pictures directly into an engineering workstation where computer-aided design...
-
Under CCP 581(b)(1), barring certain exceptions, without a court order a plaintiff has an absolute right to dismiss his or her complaint any time before the commencement of trial. Further investigate...
-
Par, Inc., is a major manufacturer of golf equipment. Management believes that Par's market share could be increased with the introduction of a cut-resistant, longer-lasting golf ball. Therefore, the...
-
Division N has decided to develop its budget based upon projected sales of 35,000 lamps at $51.00 per lamp. The company has requested that you prepare a master budget for the year. This budget is to...
-
Four key organizational complements must be in place to ensure successful implementation and use of a new system. Which two of these components seem to be missing at your store?
-
What categories of property, plant, equipment, and intangible assets does Target report in its January 30, 2016, balance sheet?
-
In Duncans company, the sudden departure of five top managers spurs the CEO to massively reorganise the hierarchical structure. Why is this NOT an example of organisation development? a. Because the...
-
What do you think is the most important thing that a manager does?
-
Which of the following is not a recommended suggestion for running an effective job interview meeting? a. Show sincerity in your vocal tone. b. Try to make the candidate feel relaxed. c. Use open...
-
Tonia Hughes, the newly appointed Chair Standards Committee of a New Zealand major city newspaper, reflected on how journalism had changed since she began as a cub reporter in 1990. Back then,...
-
Communication is often seen as a type of engineering problem concerned with ensuring that the senders message is adequately received by the receiver and not interfered with by such things as noise or...
-
Money markets are markets for O a. Long-term bonds. O b. Short-term debt securities such as Treasury bills and commercial paper. O C. Consumer automobile loans. 4 O d. Foreign currencies.
-
Critical reading SAT scores are distributed as N(500, 100). a. Find the SAT score at the 75th percentile. b. Find the SAT score at the 25th percentile. c. Find the interquartile range for SAT scores....
-
Prove that the derivation of the covariance of and in (A.10) of Appendix A. For the 18-hole courses in file golfsrs.dat, plot the weekend 18-hole greens fee vs. the backtee yardage. Estimate the...
-
Consider the random group estimator of the variance from Section 9.2.2. The parameter of interest is θ =U. A simple random sample with replacement of size n is taken from the population....
-
The data file agstrat.dat also contains information on other variables. For each of the following quantities, plot the data, and estimate the population mean for that variable along with its standard...
-
A hospitals records show that the cost of carrying out health checks in the last five accounting periods has been as follows: Using the highlow method and ignoring inflation, the estimated cost of...
-
Intermediate: Cost estimation using the linear regression formula. The management accountant at Josephine Ltd is trying to predict the quarterly total maintenance cost for a group of similar...
-
The budget for the production cost of a new product was based on the following assumptions: (i) Time for the 1 st batch of output = 10 hours (ii) Learning rate = 80 per cent (iii) Learning will cease...
Study smarter with the SolutionInn App