(a) Imidazole is a much stronger base than pyrrole (the pKa's of the conjugate acids are 7.1...
Fantastic news! We've Found the answer you've been seeking!
Question:
(a) Imidazole is a much stronger base than pyrrole (the pKa's of the conjugate acids are 7.1 and -3.8, respectively). Explain why this order of basicity occurs and show the position of protonation. 6 Marks
(b) The pyridine N-oxide, compound A, is a new drug claimed to be useful for the treatment of senile dementia. Industrial synthesis of it is outlined below.
I. Suggest a mechanism to account for Step 1 in the sequence. 5 marks
II. Suggest a mechanism to account for Step 2 in the sequence. 3 marks
III. Outline a mechanism for Step 4. 2 marks
Related Book For
Posted Date: