Although gadolinium is a metal that is very toxic to humans, it is a principal component in
Question:
Although gadolinium is a metal that is very toxic to humans, it is a principal component in many MRI contrast agents. If gadolinium is allowed to exist as a free ion in the bloodstream, it has been found to accumulate in bones and tissues and these accumulated ions have been shown to lead to adverse health effects. Magnevist (the trade name of [Gd(DTPA)]2 - ) is used to image cartilage in the body. There have been recent reports of kidney toxicity because of the release of Gd3 + from the complex. Answer complex ([Gd(DOTA )]2-) was designed to decrease the toxicity of the contrast Gent. Please explain why the Ga - DOTA complex is more stable than the Ga-DTPA complex. In your answer, be sure to describe the binding of the ligand (including the type of ligand and its denticity), as well