Some drugs are metabolised as they pass through the skin, in which case the drug-delivery process...
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Some drugs are metabolised as they pass through the skin, in which case the drug-delivery process is modelled as a diffusion-elimination equation: dc Ət 8²c = D- 8x² - kc (2) where k represents the elimination rate. (g) Non-dimensionalise equation eqn (2).¹ (h) From eqn (2), what dimensions must the elimination coefficient k have? (i) In this situation, the steady-state molar flux J depends on k as well as on Co, D and h (still depending linearly on Co). Use dimensional analysis to determine the functional dependence of J on these three quantities. (j) What restrictions would your result from part (f) impose on the nature of this depen- dence? Some drugs are metabolised as they pass through the skin, in which case the drug-delivery process is modelled as a diffusion-elimination equation: dc Ət 8²c = D- 8x² - kc (2) where k represents the elimination rate. (g) Non-dimensionalise equation eqn (2).¹ (h) From eqn (2), what dimensions must the elimination coefficient k have? (i) In this situation, the steady-state molar flux J depends on k as well as on Co, D and h (still depending linearly on Co). Use dimensional analysis to determine the functional dependence of J on these three quantities. (j) What restrictions would your result from part (f) impose on the nature of this depen- dence?
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To nondimensionalize the diffusionelimination equation 2 we need to introduce dimensionless variables Lets define the following Let C be the drug concentration in molar units Let 0 C 0 be the initial ... View the full answer
Related Book For
Accounting for Decision Making and Control
ISBN: 978-0078025747
8th edition
Authors: Jerold Zimmerman
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