i) Suggest a reason why this might be considered a good point for a first disconnection.?

ii) Fragments 14 and 15 could be connected through an amide bond formation using DCC and a base (NEt₃) as the reagents. Provide a mechanism for this reaction. (Hint: Use the general structures R1 -NH2 and R2 -CO2H to save drawing out the full structures.)

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Transcribed Image Text:

H₂N HƠ H₂N HN HN HN NHAN NHHN 14 NH₂ OH 13 || 1o0oo. HO DCC, NET OMOM 15 NH₂ NH NBoc NHBoc N=C=N om DCC H₂N HƠ H₂N HN HN HN NHAN NHHN 14 NH₂ OH 13 || 1o0oo. HO DCC, NET OMOM 15 NH₂ NH NBoc NHBoc N=C=N om DCC