Some bath salts are synthetic cathinones designed to circumvent laws, but have unknown properties and side...
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Some "bath salts" are synthetic cathinones designed to circumvent laws, but have unknown properties and side effects. The acid dissociation constant affects the toxicology of the derivatives. Electrophoretic mobility can be used to determine the pK, of a compound. Observed mobility (m²V-¹s¹) Ethedrone 2.0E-8 1.5E-8 1.0E-8 0.5E-8 0.0E-8 di 7 8 9 pH electrophoretic mobility Methylenedioxypyrovalerone At pH well below the pK, a base is in its well above the pK₁, the base is in its increases, the base goes from 10 11 Mobility of synthetic cathinones [Data from M. Woźniakiewicz, P. M. Nowak, M. Golah, M. Kata, and P. Kościelniak, "Acidity of Substituted Cathinones Studied by Capillary Electrophoresis Using the Standard and Fast Alternative Approaches," Talania 2018, 180, 193.] For weak bases like ethedrone and mthylenedioxypyrovalerone, Observed electrophoretic mobility: Hep obs= BH (Hep BH) Use this expression to explain the shape of the plot of observed electrophoretic mobility versus pH. 12 to form, and so At pH As the pH in the vicinity of the pK₁, so the form, and so with increasing pH in the vicinity of the pK₂. Electrophoretic mobility is proportional to the charge of the ion and inversely proportional to the size of the ion. Which fully protonated cathinone would be expected to have a greater electrophoretic mobility? methylenedioxypyrovalerone ethedrone Based on the electrophoretic mobility of the fully protonated base (Hep BH-), which curve is for ethedrone and which is for methylenedioxypyrovalerone? the upper curve is methlyenedioxypyrovalerone and the lower curve is ethedrone the upper curve is ethedrone and the lower curve is methlyenedioxypyrovalerone The pK, values for the two cathinones are 8.77 and 9.10. Which acid dissociation constant is for ethedrone? PK₁ = What pH would provide the greatest resolution between the two cathinones? pH <7 pH > 7 OpH=7 Some "bath salts" are synthetic cathinones designed to circumvent laws, but have unknown properties and side effects. The acid dissociation constant affects the toxicology of the derivatives. Electrophoretic mobility can be used to determine the pK, of a compound. Observed mobility (m²V-¹s¹) Ethedrone 2.0E-8 1.5E-8 1.0E-8 0.5E-8 0.0E-8 di 7 8 9 pH electrophoretic mobility Methylenedioxypyrovalerone At pH well below the pK, a base is in its well above the pK₁, the base is in its increases, the base goes from 10 11 Mobility of synthetic cathinones [Data from M. Woźniakiewicz, P. M. Nowak, M. Golah, M. Kata, and P. Kościelniak, "Acidity of Substituted Cathinones Studied by Capillary Electrophoresis Using the Standard and Fast Alternative Approaches," Talania 2018, 180, 193.] For weak bases like ethedrone and mthylenedioxypyrovalerone, Observed electrophoretic mobility: Hep obs= BH (Hep BH) Use this expression to explain the shape of the plot of observed electrophoretic mobility versus pH. 12 to form, and so At pH As the pH in the vicinity of the pK₁, so the form, and so with increasing pH in the vicinity of the pK₂. Electrophoretic mobility is proportional to the charge of the ion and inversely proportional to the size of the ion. Which fully protonated cathinone would be expected to have a greater electrophoretic mobility? methylenedioxypyrovalerone ethedrone Based on the electrophoretic mobility of the fully protonated base (Hep BH-), which curve is for ethedrone and which is for methylenedioxypyrovalerone? the upper curve is methlyenedioxypyrovalerone and the lower curve is ethedrone the upper curve is ethedrone and the lower curve is methlyenedioxypyrovalerone The pK, values for the two cathinones are 8.77 and 9.10. Which acid dissociation constant is for ethedrone? PK₁ = What pH would provide the greatest resolution between the two cathinones? pH <7 pH > 7 OpH=7
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a The plot has a sigmoidal shape like a titration curve So when a BH is equal to 1 full protonated B... View the full answer
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