Warfarin (coumadin) binds to human plasma albumin to prevent blood clotting in the reaction Measured thermodynamic values

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Warfarin (coumadin) binds to human plasma albumin to prevent blood clotting in the reaction 

Measured thermodynamic values for this reaction at 25οC are ΔG =30.8 kJ/mol, ΔH = 13.1 kJ/mol, and


(a) Determine the entropy change for this reaction at 25οC.

(b) Determine the fraction of unbound albumin over a temperature range of 0 to 50οC for a solution initially containing warfarin and albumin at 0.1 mM.

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Separation Process Principles Chemical And Biochemical Principles

ISBN: 9780470481837

3rd Edition

Authors: By J. D. Seader, Ernest J. Henley, D. Keith Roper

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