Your team is studying the problem of an intramolecular ring closure of enediyne systems important in the total synthesis of dynemicin A, which exhibits potent antitumor activity. 

One research group tried the following approaches to effect this process. Unfortunately, all were unsuccessful. Divide the schemes among yourselves and assign structures to compounds A through D. 

A successful model study (shown here) provided an alternative strategy toward the completion of the total synthesis. 

Discuss the advantages of this approach and apply it to the appropriate compound in approaches 1 through 3.

Transcribed Image Text:

H CH; СООН OH O HN ОСН H OH OH Dynemicin A