The first step in the biological degradation of histidine is formation of a 4-methylidcneirnidazol-5-one (MIO) by Cyclization
Question:
The first step in the biological degradation of histidine is formation of a 4-methylidcneirnidazol-5-one (MIO) by Cyclization of a segment of the pep- tide chain in the histidine ammonia lyase enzyme. Propose amechanism.
Transcribed Image Text:
н сн-он CH2 for -CH3 NH -СНз NHEnz NHEnz Enz Enz 4-Methylidene-5-imidazolone (MIO)
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