The polymeric resin used for Merrifield solid-phase peptide synthesis (Section 26.8) is prepared by treating polystyrene with
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The polymeric resin used for Merrifield solid-phase peptide synthesis (Section 26.8) is prepared by treating polystyrene with N-(hydroxymethyl) phthalimide and trifluoromethanesulfonic acid, followed by reaction with hydrazine. Propose a mechanism for bothsteps.
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CH2NH2 N-CH-он N. H2NNH2 CH2 CF3SO3H -CH2-CH CH2-CHt Polystyrene -CH2—Cн—
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Step 1 Polystyrene and the phthalimide combine in an electrophilic aromatic substituti...View the full answer
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