What are the known diseases caused by abnormal prions?
Answer to relevant QuestionsWhat are some diseases caused by misfolded proteins? A mutation that changes an alanine residue in a protein to an isoleucine leads to a loss of activity. Activity is regained when a further mutation at the same site changes the isoleucine to a glycine. Why? How could you isolate mitochondria from liver cells using differential centrifugation? What is the advantage to transferring proteins bands form a gel to nitrocellulose during the western blot? What are two ways that a compound can be eluted from an affinity column? What could be the advantages or disadvantages of each?
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