Refer to Exercise 18.18. Compare the mean AUCs for the three formulations using only the period 1 data. Does this analysis confirm the analysis of Exercise 18.19? Why might the analysis of Exercise 18.19 be more suitable or not be more suitable than the €œparallel€ analysis of this exercise? Supplementary Exercises Med.
In Exercise 18.18.
Many of us have been exposed to advertising related to the €œbioavailability€ of generic and brand- name formulations of the same drug product. One way to compare the bioavailability of two formulations of a drug product is to compare areas under the concentration curve (AUC) for subjects treated with both formulations. For example, the shaded area in the figure represents the AUC for a patient treated with a single dose of a drug.

A three- period crossover design was used to compare the bioavailability of two brand name (A1 and A2) and one generic version (A3) of weight-reducing agents. Three sequences of administering the drugs were used in the study:
Sequence 1: A1, A2, A3
Sequence 2: A2, A3, A1
Sequence 3: A3, A1, A2 A random sample of five subjects was assigned to each of the three sequences. The AUCs for these 15 patients are shown here.
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Transcribed Image Text:

Drug concentration Cog/mL Time (h) 3-38 1 5 202 36 48 236442122948 6. 376336 4895535457 45325255854851 ri-2-08888 51 43735 21 .4 2 7 6 3 5 7 8 721 .4 .3 123451234512345 2