In a recombinant protein expression process the host microorganism, Pichia pastoris needs to be separated from the culture supernatant after production. A pilot scale bioreactor with a working volume of 200 liters is used for this process and the final biomass concentration is 270 g/L. 

Considering the separation should be finished in 2 hour. 

If you wanted the cut time required for centrifugation to half, what would you change? Write advantages and disadvantages.