The Fries rearrangement occurs when a phenolic ester is heated with a Friedel-Crafts catalyst such as AlCl3:
Question:
The reaction may produce both ortho and para acylated phenols, the former generally favored by high temperatures and the latter by low temperatures.
(a) Suggest an experiment that might indicate whether the reaction is inter-or intramolecular.
(b) Explain the temperature effect on product formation.
Transcribed Image Text:
OH O OH AlC
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a Carry out the reaction in the presence of another aromatic compou...View the full answer
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Related Book For
Organic Chemistry
ISBN: 978-1118133576
11th edition
Authors: Graham Solomons, Craig Fryhle, Scott Snyder
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