Distinguish between the lock-and-key and induced-fit models for binding of a substrate to an enzyme.
Answer to relevant QuestionsUsing an energy diagram, show why the lock-and-key model could lead to an inefficient enzyme mechanism. The hydrolysis of a phenylalanine-containing peptide is catalyzed by a-chymotrypsin with the following results. Calculate KM and Vmax for the reaction. Peptide Concentration (M) Velocity (M min-1) 2.5 × ...What is the difference between pure and mixed noncompetitive inhibition? What features distinguish enzymes that undergo allosteric control from those that obey the Michaelis–Menten equation? Why is it necessary or advantageous for the body to make zymogens?
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