Leuprolide is a synthetic nonapeptide used to treat both endometriosis in women and prostate cancer in men.
Question:
Leuprolide is a synthetic nonapeptide used to treat both endometriosis in women and prostate cancer in men.
(a) Both C-terminal and N-terminal amino acids in Leuprolide have been structurally modified. Identify the modifications.
(b) One of the nine amino acids in Leuprolide has D stereochemistry rather than the usual L. Which one?
(c) Write the structure of Leuprolide using both one- and three-letter abbreviations.
(d) What charge would you expect Leuprolide to have at neutralpH?
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