All the organophosphate compounds listed in Table 15.1 undergo hydrolysis reactions in the same way as ATP.

Question:

All the organophosphate compounds listed in Table 15.1 undergo hydrolysis reactions in the same way as ATP. The following equation illustrates the situation for glucose-1-phosphate.

Glucose-1-phosphate + H2O → Glucose + Pi

∆G°' = 220.9 kJ mol-1

Using the free-energy values in Table 15.1, predict whether the following reactions will proceed in the direction written, and calculate the DG°' for the reaction, assuming that the reactants are initially present in a 1:1 molar ratio.

(a) ATP 1 Creatine → Creatine phosphate + ADP

(b) ATP 1 Glycerol → Glycerol-3-phosphate + ADP

(d) ATP 1 Glucose → Glucose-6-phosphate + ADP