Amine bases in nucleic acids can react with alkylating agents in typical SN2 reactions. Look at the
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Amine bases in nucleic acids can react with alkylating agents in typical SN2 reactions. Look at the following electrostatic potential maps, and tell which is the better nucleophile, guanine or adenine. The reactive positions in each areindicated.
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N7 N3 9-Methyladenine 9-Methylguanine
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