An alternative to the transient NOE experiment described in section 9.7.1 on page 274, is one in which rather than spin two being inverted by a selective 180° pulse at the start of the experiment, it is saturated. After this, there is a delay r and then a 90° pulse followed by observation, just as in the experiment described in section 9.7.1 on page 274.
In this modified experiment, the initial conditions are:
at τ = 0 : l1z(0) = I01z and I2z (0) = 0.
Using these initial conditions, analyse the experiment using the same approach as in section 9.7.1 on page 274. You should find that the NOE enhancement is given by η = (σ12τ. Sketch the expected form of the irradiated, reference and NOE difference spectra.