Question: As stated in Chapter 23, mammalian cells can become resistant to the lethal action of methotrexate by the selective survival of cells containing increases in

As stated in Chapter 23, mammalian cells can become resistant to the lethal action of methotrexate by the selective survival of cells containing increases in dihydrofolate reductase gene copy number so that intracellular levels of the enzyme become very high. What other biochemical or genetic changes in cells could cause them to become resistant to methotrexate?

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