Question: Cantharidin is a powerful vesicant that can be isolated from dried beetles (Cantharis vesicatoria, or Spanish fly). Outlined here is the stereospecific synthesis of cantharidin

Cantharidin is a powerful vesicant that can be isolated from dried beetles (Cantharis vesicatoria, or "Spanish fly"). Outlined here is the stereospecific synthesis of cantharidin reported by Gilbert Stork (Columbia University). Supply the missing reagents (a)-(n).

CO2CH3 2CH3 CO2CH3 CHOH CH2OMs 0 Ms = methanesulfonyl CH2SC2Hs CH2SC2Hs OH HIo OH (see Section 226D) (see Section 19.4) OH CHO CHOH heat -CH COH) CH CH Co2H Cantharidin

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