Question: Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the nucleotide biosynthetic intermediates that accumulate in the presence of those compounds.

Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the nucleotide biosynthetic intermediates that accumulate in the presence of those compounds.

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PRPP and FGAR accumulate because they are substrates of Reactions 2 and 5 in the IMP biosynthetic pathway Fig 231 XMP also accumulates because the GMP synthetase reaction is blocked Fig 233 Although glutamine is a substrate ... View full answer

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