Chance (Spring 2010) presented an article on the random mutation hypothesis developed by microbiologists. Under this hypothesis,
Question:
Chance (Spring 2010) presented an article on the random mutation hypothesis developed by microbiologists. Under this hypothesis, when a wild-type organic cell (e.g., a bacteria cell) divides, there is a chance that at least one of the two daughter cells is a mutant. When a mutant cell divides, both offspring will be mutant. The schematic below shows a possible pedigree from a single cell that has divided. Note that one daughter cell is mutant () and one is a normal cell ().
a. Consider a single, normal cell that divides into two offspring. List the different possible pedigrees.
b. Assume that a daughter cell is equally likely to be mutant or normal. What is the probability that a single, normal cell that divides into two offspring will result in at least one mutant cell?
c. Now assume that the probability of a mutant daughter cell is .2. What is the probability that a single, normal cell that divides into two offspring will result in at least one mutant cell?
d. The schematic below shows a possible second-generation pedigree from a single cell that has divided. The first generation mutant cell automatically produces two mutant cells in the second generation. List the different possible second generation pedigrees.
e. Assume that a daughter cell is equally likely to be mutant or normal. What is the probability that a single, normal cell that divides into two offspring will result in at least one mutant cell after the second generation?
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a Let N normal cell and M mutant cell The possible pedigrees would be NN NM MN and MM b If each daughter cell is equally likely to be normal or mutant then P N P M 5 In addition the probability of eac...View the full answer
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