Consider a problem of multiple linear regression in which a patient’s reaction Y to a new drug B is to be related to her reaction X1 to a standard drug A and her heart rate x₂. Suppose that, for all values X1 = x1 and x₂ = x₂, the regression function has the form E(Y) = β₀ + β₁x1+ β₂x₂, and the values of 10 sets of observations (x_i1, x_i2, Y_i) are given in Table 11.2 on page 696. Under the standard assumptions of multiple linear regressions, determine the values of the M.L.E.’s ˆ β₀, ˆ β₁, ˆ β₂, and ˆσ 2.