Question: EF-Tu binds all aminoacyl-tRNAs with approximately equal affinity so that it can deliver them to the ribosome with the same efficiency. Based on the experimentally

EF-Tu binds all aminoacyl-tRNAs with approximately equal affinity so that it can deliver them to the ribosome with the same efficiency. Based on the experimentally determined binding constants for EF-Tu and correctly charged and mischarged aminoacyl- tRNAs (see table), explain how the tRNA-EF-Tu recognition system could prevent the incorporation of the wrong amino acid during translation.

Aminoacyl-tRNA Ala-tRNAAb Gln- tRNAAla Gn-tRNA"In Ala-tRNACn Dissociation Constant (nM) 6.2 0.05 4.4 260

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