Gaucher disease (type I) is due to a defect in a gene that encodes a protein called acid (3-glucosidase. This enzyme plays a role in carbohydrate metabolism within the lysosome. The gene is located on the long arm of chromosome 1. People who inherit two defective copies of this gene exhibit Gaucher disease, the major symptoms of which include an enlarged spleen, bone lesions, and changes in skin pigmentation. Let's suppose a phenotypically unaffected woman, whose father had Gaucher disease, has a child with a phenotypically unaffected man, whose mother had Gaucher disease.
A. What is the probability that this child will have the disease?
B. What is the probability that this child will have two normal copies of this gene?
C. If this couple has five children, what is the probability that one of them will have Gaucher disease and four will be phenotypically unaffected?
Students also viewed these Biology questions
Hurler syndrome isduetoa mutation inagenethatencodesaproteincalled a-L-iduronidase. This...... ... neurological problems. The pedigree shown here contains three members affected with Hurler syndrome, indicated with black symbols. Based onthis pedigree, does this syndrome appear tobe an...View Answer
Muscular dystrophy in humans is caused by mutations inan X-linked genethatencodesaproteincalled dystrophin. What techniques could you use to determine ifthisgeneis active in different types of cells, say skin cells, nerve cells, and muscle...View Answer
Chapter 20 describes three blotting methods (i.e., Southern blotting, Northern blotting, and...... ... techniques to show that nurse cells transfer gene products from gene B to developing oocytes? You may assume that you can dissect the ovaries of fruit flies and isolate oocytes separately from...View Answer
Hurler syndrome, Fabry disease involves an abnormal accumulation of substances within lysosomes....... ... Thegenethatencodes ?-galactosidase Ais found onthe X chromosome. Let\'ssupposeaphenotypicallyunaffectedcouple produces two sons with Fabry diseaseandonephenotypically unaffected...View Answer
List the advantages and disadvantages of solving integer programming problems by (a) Rounding off (b) Enumeration.View Answer
Given the root locus shown inFigure P8.7, a. Find the value of gain that will make the system marginally stable. b. Find the value of gain for which the closed-loop transfer function will have a pole on the real axis at -5.View Answer
At December 31, 2016, House Co. reported the following information on its balance sheet.Accounts...... ... Prepare the journal entry to record bad debt expense for 2017, assuming that an aging of accounts receivable indicates that expected bad debts are $115,000.(d) Compute the accounts receivable...View Answer
35. Inventoriable costs are expensed on the income statement: when direct materials for the...... ... any particular time, it varies a. ?. d. 36. The following information pertains tothe Cannady Corporation: $ 50,000 Beginning work-in-process inventory Ending work-in-process inventory 48,000...View Answer
Using the trial balance provided above, prepare an income statement and statement of changes in...... ... 2017, and a balance sheet at July 31, 2017. Analysis Component: Prepare two different journal entries, including explanations, that might have created the July 31, 2017, balance in Revenue of...View Answer
Find an example of a print ad and evaluate it using the cognitive response model shown inFigure 4-4. Identify the specific types of cognitive responses that the ad might elicit from consumers and discuss why these might occur.View Answer
What is meant by encoding? Discuss how the encoding process differs for radio versus television commercials.View Answer
You have recently assumed the role of Human Resource Manager in your company. In reviewing the...... ... you build your case, use the information on the purpose of job descriptions at www.hrtools.com. a. How can job descriptions be used as a management tool? b. What role do job descriptions have in...View Answer
How much preplanning could be done for wrecks such as these in terms of disaster teams, command center locations, task sequencing, and so on?View Answer
Explain what is meant by process capability. Why is it important? What does it tell us? How can it be measured?View Answer
What is privacy in an information security context?View Answer
Myasthenia gravis is an autoimmune disease caused by T cells attacking healthy tissue. When diagnosed in early childhood, the treatment often involves the removal of the thymus.Discuss why this treatment is therapeutic for this condition based upon your knowledge of basic immunology.View Answer
Using the formulas provided in your text, determine the approximate sample sizes foreach of the following cases, all with precision (allowable error) of ±5%:a. Variability of 30%, confidence level of 95%b. Variability of 60%, confidence level of 99%c. Unknown variability, confidence level of 95%View Answer