It is often stated that proteins are quite large compared to the molecules they bind. However, what constitutes a large number depends on your point of view. Calculate the ratio of the volume of a hemoglobin molecule (65 kD) to that of the four O2 molecules that it binds and the ratio of the volume of a typical office (4 × 4 × 3 m) to that of the typical (70-kg) office worker that occupies it. Assume that the molecular volumes of hemoglobin and O2 are in equal proportions to their molecular masses and that the office worker has a density of 1.0 g/cm3. Compare these ratios. Is this the result you expected?