Question: Let's suppose you have isolated DNA from a cell and viewed it under a microscope. It looks supercoiled. What experiment would you perform to determine

Let's suppose you have isolated DNA from a cell and viewed it under a microscope. It looks supercoiled. What experiment would you perform to determine if it is positively or negatively super-coiled? In your answer, describe your expected results. You may assume that you have purified topoisomerases at your disposal.

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