Question: Polymorphism implies that each different MHC protein binds a different peptide motif. However, for the MHC class I proteins, only 6 peptide motifs can be

Polymorphism implies that each different MHC protein binds a different peptide motif. However, for the MHC class I proteins, only 6 peptide motifs can be recognized in an individual, whereas over 6000 motifs can be recognized by the entire human population. What advantage does recognition of multiple motifs have for the individual? What potential advantage does recognition of the extremely large number of motifs have for the population? Can everyone process and present the same antigens?

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